CLEARFIL™ adhesives have shown exceptional, clinical results in long-term research studies for many decades now. A systematic review of contemporary adhesives was published in 2014 and stated that “CLEARFIL™ SE showed the best bonding performance in NCCL’s” (Non-Carious Cervical Lesions)¹. This review also stated:

“This high-quality bonding performance can be explained by the presence of the functional monomer 10-MDP… This chemical bonding promoted by 10-MDP is more effective and also more stable in water than that provided by other functional monomers like 4-MET and phenyl-P.”

The original MDP monomer was developed and patented by Kuraray Co. Ltd. In 1981. The first products available with this new, unique adhesive monomer were CLEARFIL™ NEW BOND and the original PANAVIA™ EX resin cement in 1983. This unique, adhesive monomer in the right formulation creates an insoluble, chemical bond with the hydroxyapatite in dentin and enamel. It also creates a stable, chemical bond to air abraded zirconia and oxidizing metals. Therefore, MDP is what provides clinicians with a true UNIVERSAL adhesive.

“The 13-year retention rate of CLEARFIL™ SE Bond in the present clinical trial was
high (96%), as only 1 restoration was lost in each group”².

“At the 13-year recall none of the restored teeth showed post-operative sensitivity
(persistent reaction or sensitivity after air blowing or probing the restored tooth surface)”².

Many other CLEARFIL™ adhesives have similar, long-term clinical results as SE BOND. CLEARFIL™ SE Protect has the same clinical technique as SE BOND but contains a unique antibacterial monomer that provides a cavity cleansing effect as it is etching and priming instrumented tooth structure. The bond has fluoride-releasing and has been clinically proven to have no bond degradation after 1-year, In-Vivo.

Five Year Clinical Performance of An Antibacterial Adhesive System
IADR 2009, Abstract #0623³

“With its excellent retention rate, the anti-bacterial
adhesive CLEARFIL™ SE Protect can be used successfully in
high stress bearing areas of the mouth for at least five years.”

“The acid-etching of non-carious, cervical lesions prior to the application of CLEARFIL™ LINER BOND 2V
did not significantly improve the clinical performance of composite restorations after 10 years”.⁴

1. Dental Materials 30 (2014), Clinical effectiveness of contemporary adhesives for the restoration of non-carious cervical lesions. A systematic review, M. Peumansa,∗, J. De Muncka, A.Mineb, B. Van Meerbeeka a KU Leuven–BIOMAT, Department of Oral Health Sciences, KU Leuven & Dentistry,University Hospitals Leuven, Leuven, Belgium b Department of Fixed Prosthodontics, University Graduate School of Dentistry, Osaka, Japan
2. Dental Materials 31 (2015) 308–314, Thirteen-year randomized controlled clinical trial of a two-step self-etch adhesive in non-carious cervical lesions, M. Peumans, J. De Munck, K. Van Landuyta, B. Van Meerbeek, KU Leuven—BIOMAT, Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium
3. Five Year Clinical Performance of An Antibacterial Adhesive System, IADR 2009, Abstract #0623, L.S. Turkun, Ege University School of Dentistry Department of Restorative Dentistry and Endodontics, Izmir, Turkey
4. IADR 2013, Abstract 3106, Ten-Year Clinical Evaluation of Cervical Lesion Restorations using a Self-Etch Adhesive, M. Yamauti, C.A. Fernandes, L.K. Rodrigues, L.K. Rodrigues, D.S. Bezerra, M.D. Moraes, & R.M. Carvalho